Jerry is eating a cheese set in a trap while reading Good Mousekeeping. He notices someone outside, Tuffy, enters and tries to take the cheese, before Jerry pulls him. He reads a note. Jerry has been asked to take care of Tuffy over the Thanksgiving holiday by his cousin George. However, Tuffy, as the note pinned to his scarf says, "loves to eat!".
Tuffy follows Jerry into the living room, where Tom is sleeping near a bowl of milk. Jerry allows Tuffy to drink the milk from the bowl, before spotting a feast on the table in the dining room. Tuffy proceeds to eat certain foods from the table, while Jerry dresses himself and Tuffy as pilgrims, but the trouble begins when Tuffy swallows an orange whole. Jerry hits Tuffy with a knife to remove the orange. It shoots straight out of Tuffy's mouth and right into the sleeping Tom's mouth, waking him up.
After Tom's rude awakening, he sees the two mice, and wearing a feather duster as a Native American headdress, catches Tuffy. War begins. Tuffy points a gun at Tom's face. Tom leans forward at the gun as to say "go ahead take your best shot". Jerry pops a champagne cork into Tom's face. Tom returns, grabbing Jerry and about to cut him with a knife. Tuffy takes a fork, and, propels by a plate of jell-o, launches the fork into Tom's rear end. Tom yells in pain and almost lands on the fork but removes it before landing on the table. Tom picks up the fork and hurls it towards Tuffy, catching him by the diaper. As Tom catches Tuffy, Jerry runs up a nearby candlestick and hits Tom in the face with a spoon.
Tom launches flaming pussy willows, melting Jerry and Tuffy's hiding places. then Jerry takes a serving dish to shield himself and the flaming willow deflects into Tom's mouth! As they flee, Jerry runs into a knife thrown by Tom, and is knocked out cold. He makes an excited yodle. Tom grabs Jerry once again. Tuffy catapults a pie into Tom's face, knocking the cat off the table. Tuffy catapults a candle onto Tom's tail, burning the cat. Finally, Tuffy launches a champagne bottle like a missile, which hits Tom and shoots him into a cabinet. Tom surrenders, waving a white flag.
In the final scene, Tom, Jerry and Tuffy say "grace" at the table. Tuffy finishes his prayers and proceeds to devour the entire turkey before Tom and Jerry are able to pick up their cutlery, leaving Jerry's nephew with a large full stomach which he pats in delight.
- Mammy Two Shoes, who is seen in the original version of this episode, is no longer seen in this episode.
- Tom's blackface is still censored in this remake.