Neapolitan Mouse is the 86th one reel animated Tom and Jerry short, created in 1954, directed by William Hanna and Joseph Barbera and produced by Fred Quimby with music by Scott Bradley. The cartoon was animated by Ed Barge, Irven Spence, Ray Patterson and Kenneth Muse, with backgrounds by John Didrik Johnsen and layouts by Dick Bickenbach. It was released on October 2, 1954 by Metro-Goldwyn-Mayer.
The cartoon takes place in Naples, Italy, where Tom and Jerry arrive via cruise ship. Tom and Jerry's chase leads an Italian mouse named Topo to defend Jerry from Tom's attacks. Topo explains to Jerry (in Italian) that he dislikes it when a bigger creature picks on a smaller creature, which he proves when he saves Tom from being attacked by an Italian dog.
When Topo recognizes Tom and Jerry and realizes who they are, Topo explains that he's a huge fan of their cartoons and befriends them. Topo shows the duo the sights and treats them to local delicacies. But the Italian dog, along with two of his canine friends, follows behind and they eventually confront Topo while Tom and Jerry flee after they are alerted to the Italian dog and his friends' presence. However, with the help of some very large cheeses that send the dogs into the Bay of Naples, Tom, Jerry, and Topo emerge victorious, just before Tom and Jerry's ship departs for America.
Before they leave, Tom shakes Topo's hand and Jerry hugs him, and as they leave on the ship back to the United States, they're bidden farewell by Topo and, surprisingly, the three defeated dogs.
- This was the first Tom & Jerry cartoon to use the blue MGM cartoon opening title and the 1954 blue Tom & Jerry title card. Both logos, as well as the rest of the title sequences, are presented in an open-matte version unlike previous cartoons, as with many other post-1953 theatrical productions, perhaps to enable cropping for matted widescreen presentation in the movie theaters as an attempt to compete against the growing popularity of television.